Tumor-Originated Exosomal hsa-miR-3937 as a Minimally Invasive Early Biomarker for Liquid Biopsy of Colorectal Cancer

Figure 8

hsa-miR-3937 was upregulated in CRC plasma-derived exosomes. (a) TEM identifies the characteristics of plasma-derived exosomes. (b) NTA shows the distribution and size of exosomes. (c) Western blot was used the identify the markers of exosomes. (d) Exosomal hsa-miR-3937 expression levels in plasma were significantly upregulated in CRC patients when compared with healthy controls. (e) Exosomal hsa-miR-3937 expression levels were significantly upregulated in advanced (III and IV) CRC patients’ plasma. (f) Exosomal hsa-miR-3937 expression levels were significantly upregulated in T3 and T4 CRC patients’ plasma.

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