Tumor-Originated Exosomal hsa-miR-3937 as a Minimally Invasive Early Biomarker for Liquid Biopsy of Colorectal Cancer

Figure 9

Correlations between plasma exosomal hsa-miR-3937 levels and CRC clinical parameters and diagnostic power of each marker for CRC. (a) No statistical differences were observed in plasma exosomal hsa-miR-3937 levels between stages N0 and N1&N2 patients. (b) No statistical differences were observed in plasma exosomal hsa-miR-3937 levels between non-mCRC and mCRC patients. (c and d) Plasma exosomal hsa-miR-3937 levels was not associated with age and CEA level of CRC patients. (e) The AUC of exosomal hsa-miR-3937 (0.827), CEA (0.759), and CA199 (0.726), and AUC for hsa-miR-3937 combined with CEA and CA199, hsa-miR-3937 combined with CEA, and hsa-miR-3937 combined with CA199 were 0.889, 0.879, and 0.843.

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