The Effect of Alcohol Consumption in Unresectable Hepatocellular Carcinoma with Transarterial Chemoembolization

Table 3

Univariate and multivariate regression analyses for overall survival before propensity score matching.

Characteristics	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
Age (years)	0.995 (0.982, 1.009)	0.491
AST	0.999 (0.992, 1.007)	0.864
ALT	1.005 (0.999, 1.010)	0.090
Bilirubin	1.013 (0.997, 1.029)	0.124
Albumin	0.966 (0.945, 0.988)	0.003	0.978 (0.958, 0.999)	0.042
NLR	1.063 (1.012, 1.116)	0.015	1.048 (0.993, 1.107)	0.091
PLR	1.001 (0.999, 1.003)	0.190
Maximal tumor size (cm)	1.063 (1.025, 1.102)	<0.001	1.069 (1.028, 1.110)	0.001
Gender
Male	Ref	0.870
Female	0.959 (0.582, 1.580)
Smoking
Yes	Ref	0.481
No	1.107 (0.835, 1.446)
HBV infection
Yes	Ref	0.412
No	0.861 (0.602, 1.231)
HCV infection
Yes	Ref	0.498
No	0.876 (0.689, 1.212)
Cirrhosis
Yes	Ref	0.200
No	0.823 (0.611, 1.109)
Ascites
Yes	Ref	0.161
No	0.732 (0.474, 1.132)
TACE session
Once	Ref	<0.001	Ref	<0.001
Multiple times	0.325 (0.219, 0.481)		0.367 (0.244, 0.551)
Tumor number
1	Ref	0.341
≥2	1.159 (0.855, 1.572)
BCLC stage
A	Ref
B	1.526 (0.704, 3.304)	0.284
C	2.150 (0.973, 4.749)	0.058
AFP level
<200	Ref	0.245
≥200	1.191 (0.887, 1.600)
Child-Pugh
A	Ref	0.731
B	1.059 (0.764, 1.468)
ECOG score
0	Ref	0.014	Ref	0.284
1	1.444 (1.077, 1.936)		1.185 (0.869, 1.615)
Alcohol
Abstinence	Ref	0.002	Ref	0.016
Consumption	1.618 (1.194, 2.194)		1.486 (1.074, 2.055)