The Effect of Alcohol Consumption in Unresectable Hepatocellular Carcinoma with Transarterial Chemoembolization

Table 4

Univariate and multivariate regression analyses for progression-free survival before propensity score matching.

Characteristics	Univariable analysis		Multivariable analysis
	HR (95% CI)	value	HR (95% CI)	value
Age (years)	0.994 (0.981, 1.008)	0.402
AST	1.002 (0.997, 1.007)	0.410
ALT	1.000 (0.993, 1.007)	0.926
Bilirubin	1.012 (0.998, 1.026)	0.103
Albumin	0.981 (0.959, 1.003)	0.093
NLR	1.026 (0.980, 1.074)	0.276
PLR	1.000 (0.999, 1.002)	0.757
Maximal tumor size (cm)	1.068 (1.028, 1.109)	0.001	1.072 (1.032, 1.115)	<0.001
Gender
Male	Ref	0.789
Female	1.067 (0.665, 1.711)
Smoking
Yes	Ref	0.357
No	1.133 (0.869, 1.478)
HBV infection
Yes	Ref	0.803
No	1.044 (0.746, 1.460)
HCV infection
Yes	Ref	0.872
No	0.989 (0.929, 1.102)
Cirrhosis
Yes	Ref	0.076
No	0.777 (0.589, 1.026)
Ascites
Yes	Ref	0.109
No	0.719 (0.481, 1.076)
TACE session
Once	Ref	<0.001	Ref	<0.001
Multiple times	0.413 (0.279, 0.610)		0.439 (0.296, 0.652)
Tumor number
1	Ref	0.135
≥2	1.243 (0.935, 1.653)
BCLC stage
A	Ref
B	1.280 (0.626, 2.616)	0.499
C	1.503 (0.723, 3.126)	0.275
AFP level
<200	Ref	0.729
≥200	1.050 (0.795, 1.388)
Child-Pugh
A	Ref	0.523
B	1.104 (0.815, 1.495)
ECOG score
0	Ref	0.215
1	1.192 (0.903, 1.573)
Alcohol
Abstinence	Ref	0.007	Ref	0.010
Consumption	1.452 (1.109, 1.900)		1.434 (1.091, 1.886)