Inhibition of Angiogenesis by MiR-524-5p through Suppression of AKT and ERK Activation by Targeting CXCR7 in Colon Cancer Cells

Figure 7

Effects of miR-524-5p on tumor growth in vivo. (a) An image of tumor tissue. (b) Tumor volume. (c) Tumor weight. (d) The relative miR-524-5p expression. (e) Tumor tissue sections were harvested for immunohistochemical staining of CXCR7, Ki67, VEGF, AKT, p-AKT, ERK, p-ERK, and CD34. (f) The count of CD34 microvessels reflected the MVD values. (g) The relative mRNA expression of CXCR7. (h) Protein levels of CXCR7, AKT, p-AKT, ERK, p-ERK, VEGF, and PDGF.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)