The Anticancer Mechanisms of Scutellaria barbata against Lung Squamous Cell Carcinoma
Table 1
Basic information of the functional monomer component of S. barbata.
S. barbata functional monomer component name
TCMSP number
OB (%)
DL
Mechanism of anticancer (list some references)
Beta-sitosterol
MOL000358
36.91
0.75
Cytotoxic activities via inducing apoptosis and activating caspase-3 and caspase-9 [14]
Wogonin
MOL000173
30.68
0.23
Antitumor angiogenesis and negative regulation of tumor cell energy metabolism [15]
Baicalein
MOL002714
33.52
0.21
Akt/mTOR signaling pathway was downregulated, and the proliferation and migration of tumor cells were inhibited by inhibiting the expression of FAK [16]; upregulation of phosphorylation of Ste20 like kinase and activation of the Hippo signaling pathway [17]
Rhamnazin
MOL000351
47.14
0.34
Antiapoptotic effect via reduction of Bax and increase in the expression of Bcl-2; inhibit oxidative stress and inflammation [18]
Luteolin
MOL000006
36.1
0.25
Weaken the interaction on the surface of tumor cells and promote macrophage-mediated phagocytosis [19]; inhibit the phosphorylation of STAT3 and induce tumor cell apoptosis [20]
Quercetin
MOL000098
46.43
0.28
Upregulate the expression of p53, Bax, Fas, and other apoptosis-related genes and induce caspase-independent apoptosis of tumor cells [21]
Eriodictyol
MOL005190
71.79
0.24
Anticancer effects by inducing apoptosis and cell cycle arrest at the G2/M phase through restraining the mTOR/PI3K/Akt cascade [22]
Rivularin
MOL012266
37.94
0.37
Unknown
Stigmasterol
MOL000449
43.83
0.76
Induces apoptosis and protective autophagy by inhibiting the Akt/mTOR pathway [23]
Moslosooflavone
MOL008206
44.09
0.25
Unknown
Chrysin-5-methylether
MOL012251
37.27
0.2
Anticancer activity of chrysin associated with the decreased protein expression of p-ERK/ERK and p-AKT/AKT [24]
Unknown three flavonoids with the same 2-phenyl-chromone skeleton; AH5 also with the same structure, which can induce G2/M arrest and significantly apoptosis HepG-2 cell lines. AH5 induced the phosphorylation of Cdc2 and decreased the level of cyclin B1 [25]
