CircMAT2B Induced by TEAD1 Aggravates the Warburg Effect and Tumorigenesis of Oral Squamous Cell Carcinoma through the miR-942-5p/HSPD1 Axis

<div>CircMAT2B expression is transcriptionally regulated by TEAD1. Upstream transcriptional regulators of circMAT2B were predicted using the JASPAR dataset with a relative profile score threshold over 95%. (a) and (b) Relative expression of circMAT2B in Cal-27 and HSC-6 cells on si-TEAD1, si-TEAD2, si-ZNF384, and normal control (si-NC) transfection was measured by qRT-PCR. (c) The predicted binding sites between TEAD1 and MAT2B promoter regions P2 and P3. (d) and (e) Dual-luciferase reporter gene assay was applied to evaluate the interaction between TEAD1 and P2/P3 region of MAT2B promoter in Cal-27 and HSC-6 cells. Each experiment was performed three times. 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Journal of Oncology

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Figure 3

Figure 3: CircMAT2B Induced by TEAD1 Aggravates the Warburg Effect and Tumorigenesis of Oral Squamous Cell Carcinoma through the miR-942-5p/HSPD1 Axis 

Figure 3 | CircMAT2B Induced by TEAD1 Aggravates the Warburg Effect and Tumorigenesis of Oral Squamous Cell Carcinoma through the miR-942-5p/HSPD1 Axis 