Hepatoblastoma: Derived Exosomal LncRNA NEAT1 Induces BMSCs Differentiation into Tumor-Supporting Myofibroblasts via Modulating the miR-132/MMP9 Axis

Figure 8

HB-derived exosomal lncRNA NEAT1 affected the development of HB: (a–c) Characterization of tumor size, volume, and weight, (d) the expression of lncRNA NEAT1 was detected by qRT-PCR, (e) the expression of miR-132 was measured by qRT-PCR, (f–g) qRT-PCR and Western blot were used to detect MMP9 expression, respectively, (h) flow cytometry was performed to detect α-SMA and s-100 expressions, and (i) α-SMA, fibronectin, and s-100 expressions were detected by IHC (×400, 25 μm; ×100, 100 μm). versus shNC.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)