Characterization of the Lipid Metabolism in Bladder Cancer to Guide Clinical Therapy

Figure 3

Construction and verification of the prognostic index. (a) LASSO coefficients of the 18 lipid metabolism-related genes (LMRGs). (b) Identification of genes for development of prognostic risk score model. (c) Chord diagram showed the correlation between the 6 LMRGs selected through LASSO Cox regression analysis. (d) Hazard ratio of each gene after multivariate Cox regression analysis. (e) The distribution of clinical characteristics of patients in high- and low-risk score groups. (f–k) Risk scores of patients in the training cohort (TCGA), testing cohort (TCGA), and verification cohort (GEO). (l-n) Survival status of each patient in the training cohort, testing cohort, and verification cohort. (k-m) Kaplan–Meier survival analyses of patients in the training cohort (, log-rank test), testing cohort (, log-rank test), and verification cohort (, log-rank test). (o-q) AUC curve of patients in the training cohort, testing cohort, and verification cohort. (r) Meta-analysis of the training cohort, testing cohort, and verification cohort, and the results showed that the risk score was in good validity (HR = 1.49, 95% CI = 1.15–1.94, ).

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