Small Nucleolar RNA and C/D Box 15B Regulate the TRIM25/P53 Complex to Promote the Development of Endometrial Cancer

<div>SNORD15B enhanced the malignant phenotype of endometrial cancer cells in vitro. (a, b) Overexpression of SNORD15B in Ishikawa cells (a) increased the proliferation rate and (b) inhibited apoptosis. (c) Establishment of the SNORD15B-overexpressing Ishikawa cell line. (d, e) SNORD15B knockdown in HEC-1B cells (d) decreased the proliferation rate and (e) promoted apoptosis. (f) Establishment of the SNORD15B-knockdown HEC-1B cell line. (g) Overexpression of SNORD15B increased migration of Ishikawa cells in the wound healing assay. (h) Knocking down SNORD15B inhibited the migration of HEC-1B cells. (i) Overexpression of SNORD15B increased the invasiveness of the Ishikawa cell line in the Transwell assay. 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Journal of Oncology

fig2

Figure 2

Figure 2: Small Nucleolar RNA and C/D Box 15B Regulate the TRIM25/P53 Complex to Promote the Development of Endometrial Cancer 