The Role of Ferroptosis-Related Molecules and Significance of Ferroptosis Score in Cervical Cancer

Figure 2

FRGs variations and associated pathways. (a, b). The correlation between CNV, methylation, and mRNA expression levels was represented, respectively. Red bubbles mean positive correlation, and blue means negative correlation. The darker the color means the larger the correlation coefficient. The size of the bubble means FDR. (c) Oncoplots of the somatic mutation displayed the frequency of 55 FRGs mutations in CC patients. (d) Mutations in 55 FRGs among CC patients. Asterisk shows values (, ) (e) The thermogram showed the correlation of the expression of 55 FRGs in the pan-cancer signaling pathway. Pathway_a (red) indicates the percentage of cancers in which the pathway is likely activated by a particular gene, inhibition in a similar way shown as pathway_i (blue). (f) The network showed the relationship between FRGs and pathways. The solid lines indicate activation and the dashed lines indicate inhibition. (g) GO analysis revealed that many biological processes related to metabolism and oxidative stress were enriched. (h) KEGG analysis showed that the ferroptosis pathway and immune checkpoint pathways were enriched.

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