The Role of Ferroptosis-Related Molecules and Significance of Ferroptosis Score in Cervical Cancer

Figure 4

FerroScore predicted the response to chemotherapy and toxicity of erastin in combination with cisplatin on CC cells. (a) The Wilcoxon test showed the difference in PyroScore between the two clusters. (b) The bar graphs represented the distribution of t-values of the GSVA scores calculated for some pathways. (c) The bubble plot displayed the results of the correlation analysis of 55 FRGs for resistance to common clinical chemotherapy drugs in the GDSC database. (d) The Boxplot showed the difference in estimated IC50 values between the high- and low- FerroScore groups. (e, f). Different concentrations of cisplatin (0, 0.5, 1, 2 g/ml) in combination with erastin (0, 1 μM) were used in Siha, Hela cells for 24 h after cell growth and proliferation inhibition. (g) Calcusyn software calculated the two-drug combination index of cisplatin and erastin, CI < 1 indicates synergy (0.8-0.9: low synergy, 0.6–0.8: moderate synergy, 0.4–0.6: high synergy, and 0.2–0.4: strong synergy).

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