The Role of Ferroptosis-Related Molecules and Significance of Ferroptosis Score in Cervical Cancer

Figure 5

The relationship between TME, immunotherapy, and FerroScore. (a) The violin plot indicated the immune scores (stromal score, immune score, ESTIMATE score) between high- and low-FerroScore groups. (b) Relationship between the FerroScore and CD8+ cell infiltration. (c) Wilcoxon test of FerroScore variation of CD8+ cell. (d) The bubble plot revealed the correlation between FerroScore and the expression of immune cells. The color of the bubble means the value; with darker blue indicating smaller values. The larger the bubble, the stronger correlation. (e) The heat map showed the correlation between FerroScore and some immune-related scores. Red indicates a positive correlation, and blue is a negative correlation. The asterisk indicates value. (f) The boxplots for the comparison of the immune checkpoint genes between the high- and low-FerroScore groups in the CC patients. (g) The submap algorithm predicted the likelihood of response to anti-PD1 and anti-CTLA4 immunotherapy in the high and low FerroScore groups. (, , ).

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