Tetrahydrocurcumin Chemosensitizes Breast Cancer to Albumin-Bound Paclitaxel by Enhancing SPARC Expression through Demethylation

Figure 1

THC chemosensitizes BC cells to ab-PTX and increases the expression of SPARC. (a) Inhibitory effect of ab-PTX on BC cell liens at different concentrations; (c) THC enhances the inhibitory effect of ab-PTX on BC cell lines with synergistic effect. The calculated combine-treatment index was 1.161, 1.314, 1.355, and 1.159 in MDA-MB-231, MCF-7, MDA-MB-453, and SK-Br-3 cells. , compared with ab-PTX; ^##, compared with THC in same cell line. (d) THC increases the mRNA expression of SPARC gene in four BC cell lines. and , compared with DMSO.

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