Tetrahydrocurcumin Chemosensitizes Breast Cancer to Albumin-Bound Paclitaxel by Enhancing SPARC Expression through Demethylation

Figure 2

THC enhances the inhibitory effect of ab-PTX on BC tumor of nude mice. (a) The inhibitory effect on BC tumor in different groups; , compared with THC; ^##, compared with ab-PTX; (b) THC significantly increased the mRNA level of SPARC in MCF-7 xenograft tumor tissues; , compared with vehicle control; ^##, compared with ab-PTX; , compared with THC; (c) THC increased the protein level of SPARC in MCF-7 xenograft tumor tissues; , compared with vehicle control; ^##, compared with ab-PTX; , compared with THC.

(a)

(b)

(c)