Overexpressed lncRNA LINC00893 Suppresses Progression of Colon Cancer by Binding with miR-146b-3p to Upregulate PRSS8

<div>Validation of the LINC00893, miR-146b-3p, and PRSS8 in tumor tissues and adjacent normal tissues. (a) The LINC00893 expression in colon adenocarcinoma tissues based on the GEPIA tool. (b) PRSS8 relative protein expression in colon cancer tissues was measured by western blot. (c)–(e) The RNA expression levels of LINC00893, miR-146b-3p, and PRSS8 in tumor and adjacent tissue samples of colon cancer patients. (f)–(h) The clinical significance of LINC00893, miR-146b-3p, and PRSS8 was measured in colon cancer patients by ROC curves. (i) Expression correlation of LINC00893, miR-146b-3p, and PRSS8 in colon cancer tissues (<span class="nowrap"><svg height="8.55521pt" id="M33" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 34.1002 8.55521" width="34.1002pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 86L479 114C446 82 419 66 409 66C401 66 401 72 406 97C420 166 436 231 453 297C489 435 454 448 428 448C406 448 384 439 354 422C305 394 222 327 161 247H159L183 345C200 415 194 448 173 448C143 448 82 410 23 351L38 325C64 349 95 371 105 371C111 371 116 365 109 336L25 -4L31 -12C50 -4 77 3 107 9C119 69 132 122 145 168C197 254 321 381 370 381C387 381 393 374 378 305L329 95C309 17 320 -12 345 -12C372 -12 430 19 495 86Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.158,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,21.421,0)"><path d="M285 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Journal of Oncology

fig1

Figure 1

Figure 1: Overexpressed lncRNA LINC00893 Suppresses Progression of Colon Cancer by Binding with miR-146b-3p to Upregulate PRSS8 