HOXC6 Regulates the Epithelial-Mesenchymal Transition through the TGF-β/Smad Signaling Pathway and Predicts a Poor Prognosis in Glioblastoma

Figure 1

High expression and significant association of HOXC6 in GBM. The mRNA levels of HOXC6 were analyzed using the ONCOMINE gene profile database. In the images, the best gene rank percentile was used to define the color of the cells. The thresholds were gene , and value = . (b) In the heat map of HOXC6 from the TCGA datasets, the topmost bar represents the sample type, in which blue represents normal control samples, and red represents tumor samples; the color gradation at the upper right represents gene expression, in which the color changes from red to green from the top to the bottom, indicating gene expression changes from high to low; the abscissa represents sample number, and the ordinate represents gene names; each rectangle corresponds to a sample expression value. The dendrogram on the left represents cluster analysis based on differences in gene expression. (c) HOXC6 was highly expressed in high- and low-grade gliomas in the GEPIA database. (d) HOXC6 expression data in the CGGA databases with high and low expressions of HOXC6. (e) The prognostic survival rates of GBM patients with low and high HOXC6 expressions were analyzed using the GEPIA database. (f) The prognostic survival rates of LGG GBM patients with low and high HOXC6 expression were analyzed using the GEPIA database. The prognostic survival rate of glioma patients with high HOXC6 expression was low, while the risk ratio was significantly higher (). (g) Using the CGGA database, we constructed Kaplan-Meier curves for patients with high and low HOXC6 expressions. . Data are shown as the .

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