Periplocin Induces Apoptosis of Pancreatic Cancer Cells through Autophagy via the AMPK/mTOR Pathway

Figure 1

Periplocin inhibits CFPAC1 and PANC-1 cell proliferation. (a) The chemical structure of Periplocin. (b) RTCA following 24 h incubation of CFPAC1 and PANC-1 cells with Periplocin (250 nM, 125 nM) or an equal volume of DMEM media. (c) Colony formation assay following CFPAC1 and PANC-1 cells treated with Periplocin (250 nM, 125 nM) or an equal volume of DMEM medium for 24 h. The data represent the mean ± SE, with , , compared between two groups (n = 3).

(a)

(b)

(c)