miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway

<div>The radiosensitivity of BxPC3-P cells with induced ZFP57 overexpression was evaluated. (a) The ZFP57 expression was inhibited by lentiviral transfection. The ZFP57 expression was determined in BxPC3-P cells transfected with sh-ZFP57-1, sh-ZFP57-2, and the corresponding control by qPCR. After exposure of the BxPC3-P cells transfected with sh-ZFP57-2 and the corresponding control to 8 Gy irradiation, (b) the survival fraction estimated by colony formation assay. (c) Cell viability revealed by CCK-8 assay. (d) The expressions of the cell cycle-related proteins cyclin D1 and CDK4; apoptosis-related proteins Bax, Bcl-2, and cleaved caspase-3; and DNA repair-related protein <i>γ</i>-H2AX revealed by WB assay. 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Journal of Oncology

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Figure 2

Figure 2: miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway 