miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway

<div>To verify how the regulatory effect of ZFP57 on the WNT pathway affected radiosensitivity of PCC, ZFP57 overexpression was induced in BxPC3-RR cells with or without the incubation of SKL2001, followed by radiotherapy. (a) Survival fraction of the BxPC3-RR cells. (b) Cell viability. (c) Expressions of CDK4 and cyclin D1 (related to cell cycle), Bax and Bcl-2 (proteins related to apoptosis), cleaved caspase-3 (a protein related to DNA repair <i>γ</i>-H2AX), and proteins involved in the WNT pathway (d) <i>β</i>-catenin and c-Myc. <svg height="10.7395pt" id="M58" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 56.4993 10.7395" width="56.4993pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 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Journal of Oncology

fig5

Figure 5

Figure 5: miR-193a-5p Enhances the Radioresistance of Pancreatic Cancer Cells by Targeting ZFP57 and Activating the Wnt Pathway 