Research Article
Value of Cytokine Expression in Early Diagnosis and Prognosis of Tumor Metastasis
Table 1
Baseline characteristics of the study cohort according to metastasis.
| | Clinical characteristics | Nonmetastasis (n = 26) | Metastasis (n = 108) | |
| | Age (mean (SD)) | 55.69 (11.81) | 58.59 (13.03) | 0.302 | | Gender | | Female | 7 (26.9%) | 45 (41.7%) | 0.246 | | Male | 19 (73.1%) | 63 (58.3%) | | Stage | | I | 3 (11.5%) | 0 (0.0) | <0.001 | | II | 6 (23.1%) | 0 (0.0) | | III | 16 (61.5%) | 0 (0.0) | | IV | 1 (3.8%) | 108 (100.0%) | | IL-1β (mean (SD)) | 4.66 (6.23) | 7.73 (26.33) | 0.557 | | IL-2 (mean (SD)) | 0.99 (0.91) | 1.24 (2.23) | 0.571 | | IL-4 (mean (SD)) | 1.36 (0.81) | 1.38 (1.84) | 0.950 | | IL-5 (mean (SD)) | 5.16 (15.78) | 2.87 (6.34) | 0.242 | | IL-6 (mean (SD)) | 12.51 (29.80) | 36.54 (77.84) | 0.125 | | IL-8 (mean (SD)) | 1.30 (0.88) | 10.84 (35.80) | 0.178 | | IL-10 (mean (SD)) | 2.71 (3.29) | 2.28 (2.85) | 0.500 | | IL-12p70 (mean (SD)) | 2.97 (6.23) | 1.18 (0.60) | 0.004 | | IL-17 (mean (SD)) | 1.50 (0.70) | 2.23 (4.70) | 0.435 | | TNF-α (mean (SD)) | 2.09 (1.08) | 2.95 (4.27) | 0.311 | | IFN-γ (mean (SD)) | 4.45 (8.05) | 6.65 (16.18) | 0.502 | | IFN-α (mean (SD)) | 1.64 (2.18) | 2.39 (6.10) | 0.542 | | Hb (mean (SD)) | 124.23 (24.40) | 111.72 (23.14) | 0.016 | | LY number (mean (SD)) | 1.54 (0.55) | 1.27 (0.65) | 0.049 | | LY% (mean (SD)) | 32.05 (11.60) | 22.49 (12.67) | 0.001 | | MO number (mean (SD)) | 0.40 (0.18) | 0.49 (0.26) | 0.108 | | MO% (mean (SD)) | 7.85 (2.64) | 7.87 (3.19) | 0.968 | | NEUT number (mean (SD)) | 3.04 (1.66) | 4.89 (3.91) | 0.020 | | NEUT% (mean (SD)) | 56.46 (13.56) | 66.90 (14.18) | 0.001 | | PLT number (mean (SD)) | 183.50 (63.44) | 229.33 (111.59) | 0.046 | | WBC number (mean (SD)) | 5.17 (1.72) | 6.82 (4.04) | 0.045 |
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Analyzed by the Wilcoxon test, . Abbreviations. Hb, hemoglobin; LY, lymphocyte; MO, monocyte; NEUT, neutrophil; PLT, platelet; WBC, white blood cell. |
