A Novel Tool to Predict the Overall Survival of High-Grade Osteosarcoma Patients after Neoadjuvant Chemotherapy: A Large Population-Based Cohort Study

Table 2

Analysis of univariate and multivariate Cox regression in high-grade osteosarcoma patients after neoadjuvant chemotherapy.

Characteristics	Univariate analysis		Multivariate analysis
	HR (95% CI), P value		HR (95% CI), P value
Age
<16	Reference		Reference
16–21	1.238 (0.869–1.766)	0.237	1.287 (0.899–1.841)	0.168
>21	2.140 (1.526–3.002)	<0.001	2.597 (1.838–3.670)	<0.001
Race
Black	Reference
White	0.880 (0.604–1.281)	0.504
Others	1.120 (0.632–1.983)	0.698
Sex
Male	Reference
Female	0.808 (0.603–1.082)	0.152
Primary site
Upper limb	Reference
Lower limb	0.655 (0.452–0.948)	0.025
Others	1.401 (0.711–2.759)	0.330
Grade
III	Reference
IV	0.867 (0.646–1.164)	0.342
Laterality
Left—origin of primary	Reference
Right—origin of primary	1.080 (0.811–1.438)	0.600
Radiotherapy
No	Reference
Yes	1.594 (0.749–3.394)	0.226
Postoperative chemotherapy
No	Reference
Yes	0.730 (0.546–0.975)	0.033
Tumor size
<64	Reference		Reference
64–139	2.596 (1.432–4.708)	0.002	2.135 (1.168–3.905)	0.014
>139	4.208 (2.269–7.804)	<0.001	3.134 (1.680–5.881)	<0.001
Disease stage
Localized	Reference		Reference
Regional	1.687 (1.122–2.536)	0.012	1.587 (1.051–2.396)	0.028
Distant	4.141 (2.699–6.353)	<0.001	4.145 (2.670–6.436)	<0.001
Marital status
Unmarried	Reference
Married	1.620 (1.063–2.469)	0.025