M2 Tumor Associate Macrophage- (TAM-) Derived lncRNA HISLA Promotes EMT Potential in Bladder Cancer

<div>TAM-derived exosomes promotes migration, invasion, and EMT process of bladder cancer cells. (a) PKH67-labelled TAM exosomes were shown to be taken up by T24 BC cells. (b, c) Wound healing assay was performed to detect the effect of TAM-derived exosomes on migration of T24 and HTB-1 cells. (d, e) Transwell assay (without matrigel) was used to illustrate the effect of TAM-exo on cell migration. (f, g) Transwell assay (with matrigel) was used to illustrate the effect of TAM-exo on cell invasion. (h) EMT markers such as E-cadherin, N-cadherin, Vimentin, VEGF, and Snail were detected by western blot assay after TAM-exo treatment in T24 and HTB-1 cells. 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Journal of Oncology

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Figure 2

Figure 2: M2 Tumor Associate Macrophage- (TAM-) Derived lncRNA HISLA Promotes EMT Potential in Bladder Cancer 