Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo

<div>Propofol markedly repressed cell viability, migration, and invasion and upregulated caspase 3 expression in CRC cells. (a) HCT-116 and LoVo cell migration was evaluated using the wound healing assay after the cells had been treated with low or high doses of propofol. (b) CCK-8 assays were used to examine the viability of HCT-116 and LoVo cells treated with propofol. (c) Transwell assays revealed changes in the invasiveness of propofol-treated HCT-116 and LoVo cells, and the numbers of invasive cells were counted. (d) The levels of caspase 3 protein expression in HCT-116 and LoVo cells treated with propofol were detected by western blotting. (e) Caspase 3 activity in propofol-treated HCT-116 and LoVo cells was assessed using the appropriate ELISA kit.</div>

Journal of Oncology

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Figure 1

Figure 1: Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo 

Figure 1 | Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo 