Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo

<div>Propofol reduced glycolysis in CRC cells. HCT-116 and LoVo cells were treated with low or high doses of propofol, respectively. (a) ATP levels in the cells were determined using an ATP assay kit. (b) A lactate assay kit was used to identify changes in lactic acid content. (c) A glucose assay kit was used to analyze changes in glucose consumption. (d) Western blotting was performed to detect changes in HK2, PKM2, and LDHA protein expression. (e) An 8-OHdG assay kit was used to monitor the effect of propofol on 8-OHdG levels.</div>

Journal of Oncology

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Figure 2: Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo 

Figure 2 | Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo 