Propofol Prevents the Growth, Migration, Invasion, and Glycolysis of Colorectal Cancer Cells by Downregulating Lactate Dehydrogenase Both In Vitro and In Vivo

Figure 6

Propofol markedly inhibited glycolysis in the CRC model mice. (a) Immunochemistry assays were performed to detect 8-OHDG expression in each group of tumors. (b) An 8-OHdG assay kit was used to examine the effect of propofol on 8-OHdG levels. (c) Changes in tumor lactic acid levels were detected with a lactate assay kit. (d) The levels of HK2, PKM2, and LDHA expression in each group of tumors were examined by western blotting. (e) MMP2 and MMP9 expressions in each group of tumors were detected by western blotting.

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