Journal of Oncology

Research Article

Clinical Characteristics, Outcomes, and Risk Factors for Patients with Diffuse Large B-Cell Lymphoma and Development of Nomogram to Identify High-Risk Patients

Table 2

Risk factors for survival in patients with DLBCL.


Variables	Univariate, value	Multivariate
Variables	Univariate, value	HR	95%	value

Male	0.045			0.151
Age > 60	<0.001	2.086	1.371–3.175	<0.001
ECOG > 1	<0.001	2.666	1.790–3.970	0.001
With B symptom	0.001			0.656
Ann Arbor stage III-IV	<0.001	1.857	1.035–3.333	0.038
IPI > 2	<0.001
Non-GCB (reference GCB)	0.042			0.393
Ki-67 > 90%	0.251
Bulky disease	0.148
BM involvement	<0.001	2.024	1.413–2.898	<0.001
CNS involvement	0.007			0.381
No. of extranodal sites > 1	0.001			0.194
Evaluated LDH	<0.001			0.083
Evaluated D-dimer	0.063			0.873
Low LMR	0.001	1.605	1.128–2.283	0.015
Low ALB	<0.001	1.548	1.088–2.202	0.008
HbsAg positive	0.808

ECOG, Eastern Cooperative Oncology Group; GCB, germinal center B-cell; CNS, central nervous system; LDH, lactate dehydrogenase; LMR, lymphocyte-monocyte ratio; value was calculated by Cox regression, and is regarded significant.