GABPB1-AS1 Promotes the Development of Osteosarcoma by Targeting SP1 and Activating the Wnt/<i>β</i>-Catenin Pathway

<div>SP1 is essential for the biological function of osteosarcoma cells mediated by GABPB1-AS1. (a) qRT-PCR detects the effect of silencing GABPB1-AS1 on the expression of SP1 in osteosarcoma cells. (b) Colony formation detection of SP1 overexpression on the salvage effect of GABPB1-AS1 deletion on cell proliferation inhibition. (c) Transwell tested the rescue effect of SP1 overexpression on GABPB1-AS1 deficiency that hinders cell invasion, scale bar = 100 <i>μ</i>m. (d) qRT-PCR detects the level of EMT biomarker E-cadherin in different treated cells. (e) qRT-PCR detects the level of EMT biomarker N-cadherin in different treated cells. (f) qRT-PCR detects the level of EMT biomarker Slug in different treatment cells. 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Journal of Oncology

fig3

Figure 3

Figure 3: GABPB1-AS1 Promotes the Development of Osteosarcoma by Targeting SP1 and Activating the Wnt/<i>β</i>-Catenin Pathway 

Journal of Oncology

GABPB1-AS1 Promotes the Development of Osteosarcoma by Targeting SP1 and Activating the Wnt/β-Catenin Pathway

Figure 3