Upregulation of PNCK Promotes Metastasis and Angiogenesis via Activating NF-κB/VEGF Pathway in Nasopharyngeal Carcinoma

Figure 3

Role of PNCK in the in vivo metastasis and angiogenesis model of NPC. (a) Representative images and (b) quantification of lung metastatic foci in mice after injecting SUNE-1 cells with overexpression of PNCK or control vector by tail vein injection. Arrows indicate surface metastatic nodules. (c) Alignment of PNCK amino acid sequences of human and zebrafish. (d) The schematic diagram of RNA-editing technology in the zebrafish embryo. (e) Fluorescence intensity of intersegmental vessels in Tg (fli1a: EGFP) embryos inoculated with blank, control, or PNCK KD vector. ANOVA, . (f) Fluorescence intensity of intersegmental vessels in Tg (fli1a: EGFP) embryos inoculated with control or PNCK vector. Student’s -test, .

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