Research Article

Effects of Different Organ Metastases on the Prognosis of Stage IV Urothelial Carcinoma of the Bladder

Table 1

Baseline factors associated with the presence of distant metastases at diagnosis of UBUC (n, %).

VariableDistant metastasis (n = 1035)Without distant metastasis (n = 2068)

Age, y
 <407 (0.7)14 (0.7)
 <60215 (20.8)495 (23.9)
 <80587 (56.7)1206 (58.3)
 ≥80226 (21.8)353 (17.1)
Sex
 Female278 (26.9)629 (30.4)
 Male757 (73.1)1439 (69.6)
Year of diagnosis
 2010151 (14.6)370 (17.9)
 2011153 (14.8)338 (16.3)
 2012188 (18.2)310 (15.0)
 2013152 (14.7)342 (16.5)
 2014181 (17.5)342 (16.5)
 2015210 (20.3)366 (17.7)
Race
 White878 (84.8)1781 (86.1)
 Black108 (10.4)185 (8.9)
 Other49 (4.7)102 (4.9)
Histology
 Transitional cell carcinoma1001 (96.7)1953 (94.4)
 No transitional cell carcinoma34 (3.3)115 (5.6)
T stage
 T09 (0.9)6 (0.3)
 T1141 (13.6)102 (4.9)
 T2456 (44.1)618 (29.9)
 T397 (9.4)671 (32.4)
 T4196 (18.9)604 (29.2)
 TX136 (13.1)67 (3.2)
N stage
 N0569 (55.0)289 (14.0)
 N1103 (10.0)694 (33.6)
 N2173 (16.7)830 (40.1)
 N356 (5.4)212 (10.3)
 NX134 (12.9)43 (2.1)
Grade
 I–II18 (1.7)33 (1.6)
 III–IV819 (79.1)1855 (89.7)
 Unknown198 (19.1)180 (8.7)
Surgery primary site
 None227 (21.9)153 (7.4)
 TURB638 (61.6)597 (28.9)
 Partial cystectomy5 (0.5)39 (1.9)
 Radical cystectomy31 (3.0)536 (25.9)
 Pelvic exenteration34 (3.3)638 (30.9)
 Other100 (9.7)105 (5.1)

UBUC, urinary bladder urothelial carcinoma; TURB, transurethral resection of the bladder.