Expression Profiles of HOXC6 Predict the Survival of Glioblastoma Patients and Correlate with Cell Cycle

Figure 4

GO cellular component analysis and KEGG pathway enrichment analysis. (a) Merged top 5 GO terms enriched either in DEGs or genes highly correlated with HOXC6. (b) Merged top 5 KEGG pathways enriched either in DEGs or genes highly correlated with HOXC6. (c) Yellow circles represent the top 5 GO cellular components enriched in genes highly correlated with HOXC6, whereas brown circles represent the enriched genes. (d) KEGG pathway analysis based on genes highly correlated with HOXC6. Colored rectangles represent the highly correlated genes, and the color bar indicates the log2-fold change of genes between the high-expression group and the low-expression group of HOXC6. GSEA and heat map represents GSEA results. (e) GSEA was performed in patients sorted by HOXC6 expression value. Above: biological process, genes associated with positive regulation of cell cycle process, cell cycle, and mitotic cell cycle are enriched in patients with high levels of HOXC6 expression; center: cellular component, genes associated with spindle midzone, condensed nuclear chromosome, and condensed chromosome are enriched in patients with high levels of HOXC6 expression; below: KEGG pathway, genes associated with cell cycle, mismatch repair, and proteasome pathways are enriched in patients with high levels of HOXC6 expression. The horizontal bar in graded color from red to blue represents the rank ordering of patients based on decreasing levels of HOXC6 expression. Vertical black lines represent the projection of individual genes constituting relevant gene sets. (f) Heat map showing enriched genes from the GSEA gene sets of Figure 4(e) in combination with the HOXC6 expression value. DEG: differentially expressed gene; COR: highly correlated gene.

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