A New Model for Predicting Nonsentinel Lymph Node Metastasis in Early-Stage Breast Cancer Using MMP15
Table 2
Univariate logistic regression analysis of factors related to NSLN metastases.
Variables
Univariate analysis
95% CI
158
value
HR
Lower
Upper
Age (years)
>50 versus ≤50
0.833
0.933
0.492
1.772
Tumor type
Others† versus invasive ductal carcinoma
0.664
0.759
0.218
2.635
Tumor size (cm)
0.005
1.784
1.19
2.675
Histological grade
III versus I–II
0.552
0.773
0.33
1.809
Lymphovascular invasion
Yes versus no
0.011
2.556
1.236
5.286
Neural invasion
Yes versus no
0.014
14.074
1.714
115.567
Size of the SLN metastasis
Macrometastasis versus micrometastasis
0.115
3.488
0.738
16.494
Expression of MMP15 in cytoplasm
Positive versus negative
0.006
2.503
1.294
4.842
Expression of MMP15 in nucleus
Positive versus negative
0.356
1.63
0.578
4.596
Number of positive SLNs
≤0.001
2.153
1.5
3.09
Number of negative SLNs
0.002
0.718
0.58
0.888
Molecular subtype
Luminal B versus luminal A
0.248
3.714
0.401
34.443
HER2 overexpression versus luminal A
0.207
4
0.465
34.432
Triple negative versus luminal A
0.116
8
0.598
106.936
Ki-67 status
>0.2 versus ≤0.2
0.137
1.629
0.856
3.099
Tumor quadrant
Outer upper versus others
0.288
0.704
0.369
1.344
Multifocality
Yes versus no
0.526
1.586
0.382
6.591
Percentage of positive SLNs
≤0.001
20.008
4.736
84.523
PLR
0.407
0.997
0.989
1.004
NLR
0.033
0.619
0.398
0.963
NMR
0.057
0.917
0.838
1.003
†Invasive lobular carcinoma, mixed carcinoma (invasive ductal carcinoma and invasive lobular carcinoma), tubular carcinoma, mucinous adenocarcinoma, papillary carcinoma, and sweaty adenoid carcinoma; SLNs, sentinel lymph nodes; MMP15, matrix metalloproteinase 15; PLR, the ratio of the absolute number of platelets to the absolute number of lymphocytes; NLR, the ratio of the absolute number of neutrophils to the absolute number of lymphocytes; NMR, the absolute number of neutrophils to the absolute number of monocytes.
