The tRNA-Derived Fragment tRF-24-V29K9UV3IU Functions as a miRNA-like RNA to Prevent Gastric Cancer Progression by Inhibiting GPR78 Expression

<div>tRF-24-V29K9UV3IU inhibits the biological functions of GC cells by regulating GPR78 expression. (a) Representative images and (b) statistical results of flow cytometry analysis utilized to determine the number of apoptotic cells in four groups. (c) Cell proliferation assays of MKN-45 cells overexpressing tRF-24-V29K9UV3IU. (d) Transwell assays were used to detect the effect of overexpression of tRF-24-V29K9UV3IU on MKN-45 cell migration (d) and invasion (e). These results showed that overexpression of tRF-24-V29K9UV3IU promoted apoptosis, suppressed proliferation, migration, and invasion, while overexpression of BBB was opposite, and overexpression of GPR78 weakened the function of tRF-24-V29K9UV3IU. The above experiments were repeated three times. 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Journal of Oncology

fig6

Figure 6

Figure 6: The tRNA-Derived Fragment tRF-24-V29K9UV3IU Functions as a miRNA-like RNA to Prevent Gastric Cancer Progression by Inhibiting GPR78 Expression 

Figure 6 | The tRNA-Derived Fragment tRF-24-V29K9UV3IU Functions as a miRNA-like RNA to Prevent Gastric Cancer Progression by Inhibiting GPR78 Expression 