Research Article
Ketamine Does Not Change Natural Killer Cell Cytotoxicity in Patients Undergoing Cancer Surgery: Basic Experiment and Clinical Trial
Table 1
The characteristics of the patients who underwent lung (lobectomy) or prostate cancer surgery (RARP).
| | Control | Ketamine | MD (95% CI) | value |
| | Age (yrs) | | | 0.9 (−2.0, 3.9) | 0.54 | | Height (cm) | | | 0.1 (−3.5, 3.7) | 0.96 | | Weight (kg) | | | −1.8 (−6.3, 2.69 | 0.41 | | Anesthesia (min) | | | −7.2 (−28.9, 14.4) | 0.51 | | Surgery (min) | | | −6.6 (−26.5, 13.3) | 0.51 | | Propofol (mg) | | | −103.0 (−288.2, 82.2) | 0.27 | | Remifentanil (μg) | | | −288.6 (−620.3, 43.1) | 0.09 | | Ketamine (mg) | 0 | | −134.0 (−142.4, −125.6) | <0.001 | | Fentanyl (μg) | | | 7 (19, 32) | 0.61 | | Morphine (mg) | 10 [10, 10] | 10 [10, 10] | NA | 0.76 | | Aceta (mg) | | | −17.3 (−92.9, 58.1) | 0.65 | | ΔNLR | 6.0 [2.3, 15.5] | 6.2 [2.6, 14.6] | NA | 0.75 | | ΔPLR | −6.4 [−15.4, 12.2] | −3.6 [−12.8, 20.6] | NA | 0.27 | | NRS | 0 [0, 3] | 0 [0, 2.3] | NA | 0.79 |
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ΔNLR and ΔPLR = value before-after surgery. Aceta: acetaminophen; MD: mean difference; NA: not analyzed; NLR: neutrophil-lymphocyte ratio; NRS: numerical rating scale; PLR: platelet-lymphocyte ratio; RARP: robot-assisted radical prostatectomy.
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