Research Article
Identification and Validation of a Novel Multiomics Signature for Prognosis and Immunotherapy Response of Endometrial Carcinoma
Table 2
22 key molecules identified by LASSO-Cox regression.
| | Molecules | Annotation | Coefficient |
| | ACVR1 (Activin A Receptor Type 1) | Mutation | −0.31351085 | | ARID1A (AT-Rich Interaction Domain 1A) | Mutation | −0.230538257 | | ATM (Ataxia Telangiectasia Mutated) | Mutation | −0.095420173 | | BIRC6 (Baculoviral IAP Repeat Containing 6) | Mutation | −0.13931703 | | ERBB3 (Erb-B2 Receptor Tyrosine Kinase 3) | Mutation | −0.167684278 | | HOXA11 (Homeobox A11) | Mutation | 0.340669897 | | POLE (DNA Polymerase Epsilon) | Mutation | −0.18491545 | | POLQ (DNA Polymerase Theta) | Mutation | −0.035077258 | | SPOP (Speckle Type BTB/POZ Protein) | Mutation | −0.094758819 | | GINS4 (SLD5,GINS Complex Subunit 4) | CNV | 0.058592508 | | GORAB (Golgin, RAB6 Interacting) | CNV | 0.074299734 | | GSTM1 (Glutathione S-Transferase Mu 1) | CNV | 0.172758754 | | KCNMB3 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3) | CNV | −0.111711137 | | PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) | DEG | −0.074886487 | | CDH18 (Cadherin 18) | DEG | 0.197447688 | | KCNK3 (Potassium Two Pore Domain Channel Subfamily K Member 3) | DEG | 0.047114247 | | PCSK1 (Proprotein Convertase Subtilisin/Kexin Type 1) | DEG | 0.114882922 | | KCNJ12 (Potassium Inwardly Rectifying Channel Subfamily J Member 12) | DEG | 0.131411471 | | NCMAP (Non-Compact Myelin Associated Protein) | DEG | −0.024703756 | | cg07792478 | CpG of IR124-2 | 0.327359364 | | cg13703871 | CpG of NF177 | 0.583394392 | | cg14398860 | CpG of INPP5A | 0.133967149 |
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(CNV, copy number variance; DEG, differentially expressed genes)
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