Synergistic Lethality Effects of Apatinib and Homoharringtonine in Acute Myeloid Leukemia

Table 2

The effect of synergistic inhibition in AML cell lines.

MV4-11
Concentration		24 h		48 h
Apa	HHT	Fa	CI	Fa	CI
2.5	2	0.14	0.1927	0.36	0.1244
5	4	0.18	0.2579	0.38	0.2191
10	8	0.19	0.4723	0.50	0.2153
20	16	0.39	0.2584	0.72	0.1136
MOLM-13
Concentration		24 h		48 h
Apa	HHT	Fa	CI	Fa	CI
2.5	2	0.12	0.5103	0.14	0.5988
5	4	0.17	0.3835	0.22	0.5731
10	8	0.20	0.5256	0.49	0.2373
20	16	0.38	0.2088	0.75	0.1181
OCI-AML2
Concentration		24 h		48 h
Apa	HHT	Fa	CI	Fa	CI
2.5	2	0.18	0.1715	0.08	0.9547
5	4	0.24	0.128	0.20	0.4447
10	8	0.25	0.2212	0.50	0.1198
20	16	0.39	0.0764	0.71	0.0660
OCI-AML3
Concentration		24 h		48 h
Apa	HHT	Fa	CI	Fa	CI
2.5	2	0.07	0.5814	0.28	0.080
5	4	0.14	0.3159	0.35	0.0563
10	8	0.28	0.1578	0.42	0.0435
20	16	0.37	0.1682	0.57	0.0126

Fa: fraction affected.