The HBV Specially-Related Long Noncoding RNA HBV-SRL Involved in the Pathogenesis of Hepatocellular Carcinoma

Figure 1

Differentially expressed lncRNAs between HCC tumors with or without HBV infection. (a) Microarray analysis found differential expression of lncRNA between tumor tissues with HBV (HBV⁺T) and that without HBV (HBV⁻T). (b) Bioinformatic analysis of differently expressed lncRNAs (fold change > 2) between tumor tissues with HBV (HBV⁺T) and that without HBV (HBV⁻T) or tumor tissues and corresponding parenchyma tumor tissues (PT). (c) Real-time PCR analysis of 4-candidate lncRNAs expression in tumor tissues (T) and corresponding parenchyma tumor tissues (PT) without (A) or with HBV (B). (d) Real-time PCR analysis of lncRNA AK128595 expression in tumor tissues (HBV⁺T) and corresponding parenchyma tumor tissues (HBV⁺PT) from patients with HBV (n = 30). The error bars represent the standard deviation (SD) of data obtained in at least three independent experiments, .

(a)

(b)

(c)

(d)