The HBV Specially-Related Long Noncoding RNA HBV-SRL Involved in the Pathogenesis of Hepatocellular Carcinoma

Table 2

Univariate analyses of factors associated with survival and recurrence for 222 HCC patients.

Factor	OS	DFS
	Age (yr)
>60 Vs ≤ 60	0.427	0.008
Sex
Male vs. female	0.417	0.107
HBsAg
Positive vs. negative	0.53	0.374
HBV DNA
>10^4 Vs ≤ 10^4	<0.001	<0.001
AFP (μg/L)
>20 Vs ≤ 20	0.004	0.003
ALT (U/L)
>41 Vs ≤ 41	0.209	0.028
AST (U/L)
>37 Vs ≤ 37	0.002	<0.001
Tumor number
Multiple vs. single	0.009	<0.001
Liver cirrhosis
Yes vs. no	0.156	0.598
Tumor size (cm)
>5 Vs ≤ 5	<0.001	<0.001
Micrometastases
Yes Vs. no	<0.001	<0.001
Tumor encapsulation
Yes Vs. no	<0.001	<0.001
Microvascular invasion
Yes Vs no	0.013	<0.001
HBV-SRL
High Vs. low	0.002	0.043
NF-κB2
High Vs. low	0.001	0.041

OS, overall survival; DFS, disease-free survival; PVTT, portal vein tumor thrombus; HBsAg, hepatitis B surface antigen; HBV DNA, hepatitis B virus deoxyribonucleic acid; TNM, tumor-node metastasis; AFP, α-fetoprotein; NA, not adopted; NS, not significant; Low/high, HBV-SRL, and NFκB levels were lower/higher than the median value.