Research Article
Integrated Bioinformatics Analysis for Identifying the Significant Genes as Poor Prognostic Markers in Gastric Adenocarcinoma
Table 2
Gene ontology analysis of differentially expressed genes in gastric adenocarcinoma.
| | Expression | Category | Term | Count | % | -value | FDR |
| | Upregulated | GOTERM_BP_DIRECT | GO:0035987∼endodermal cell differentiation | 3 | 15.0 | 2.41E − 04 | 0.277424 | | GOTERM_BP_DIRECT | GO:0030199∼collagen fibril organization | 3 | 15.0 | 3.59E − 04 | 0.413041 | | GOTERM_BP_DIRECT | GO:0070208∼protein heterotrimerization | 2 | 10.0 | 0.007132 | 7.921921 | | GOTERM_BP_DIRECT | GO:0043589∼skin morphogenesis | 2 | 10.0 | 0.007132 | 7.921921 | | GOTERM_BP_DIRECT | GO:0007155∼cell adhesion | 3 | 15.0 | 0.008542 | 9.418433 | | GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 8 | 40.0 | 4.61E − 05 | 0.038561 | | GOTERM_CC_DIRECT | GO:0005581∼collagen trimer | 3 | 15.0 | 0.001285 | 1.069804 | | GOTERM_CC_DIRECT | GO:0005584∼collagen type I trimer | 2 | 10.0 | 0.002491 | 2.064654 | | GOTERM_CC_DIRECT | GO:0005578∼proteinaceous extracellular matrix | 3 | 15.0 | 0.014327 | 11.37209 | | GOTERM_MF_DIRECT | GO:0005201∼extracellular matrix structural constituent | 3 | 15.0 | 5.25E − 04 | 0.415248 | | GOTERM_MF_DIRECT | GO:0008201∼heparin binding | 2 | 10.0 | 0.087398 | 51.56318 |
| | Downregulated | GOTERM_BP_DIRECT | GO:0007586∼digestion | 5 | 10.2 | 1.81E − 05 | 0.023045 | | GOTERM_BP_DIRECT | GO:0010107∼potassium ion import | 4 | 8.2 | 4.56E − 05 | 0.058116 | | GOTERM_BP_DIRECT | GO:0055114∼oxidation-reduction process | 7 | 14.3 | 0.003333 | 4.16404 | | GOTERM_BP_DIRECT | GO:0015701∼bicarbonate transport | 3 | 6.1 | 0.005406 | 6.671731 | | GOTERM_CC_DIRECT | GO:0005615∼extracellular space | 11 | 22.4 | 0.001646 | 1.61346 | | GOTERM_CC_DIRECT | GO:0005764∼lysosome | 5 | 10.2 | 0.002499 | 2.44067 | | GOTERM_CC_DIRECT | GO:0016324∼apical plasma membrane | 5 | 10.2 | 0.006137 | 5.897225 | | GOTERM_CC_DIRECT | GO:0005887∼integral component of plasma membrane | 10 | 20.4 | 0.008007 | 7.631398 | | GOTERM_CC_DIRECT | GO:0016021∼integral component of membrane | 22 | 44.9 | 0.009103 | 8.634041 | | GOTERM_MF_DIRECT | GO:0005242∼inward rectifier potassium channel activity | 3 | 6.1 | 7.31E − 04 | 0.820368 | | GOTERM_MF_DIRECT | GO:0008900∼hydrogen:potassium-exchanging ATPase activity | 2 | 4.1 | 0.00603 | 6.584128 | | GOTERM_MF_DIRECT | GO:0015467∼G-protein activated inward rectifier potassium channel activity | 2 | 4.1 | 0.019965 | 20.31405 |
|
|
