Identification of TIMP2 as a Prognostic Biomarker and Its Correlation with Tumor Immune Microenvironment: A Comprehensive Pan-Cancer Analysis

Figure 1

Genomic alterations and mRNA expression landscape of TIMP2 in different types of cancers. (a) The genetic alteration type and frequency of TIMP2 in diverse malignancies. The results are displayed as a histogram of the alteration frequencies of TIMP2 across cancer studies. The genetic alteration type and frequency included amplification (red), deep deletions (blue), mutation (green), fusion (purple), and multiple alterations (grey). Color images are available online. (b) The Oncomine database showed high or low expression of TIMP2 in various cancer tissues compared with normal tissues. Red and blue stand for the numbers of datasets with statistically significant () increased and decreased levels of PTPN family genes. (c) Transcripts per million (TPM) of TIMP2 in different cancer types from TCGA and GTEx data. The red fusiformis represents tumor tissue, and the blue fusiformis represents normal tissue. T: tumor; N: normal; n: number; X axis: number of tumor and normal samples; Y axis: transcript per million (log2 (TPM+ 1)). , , and .

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