The Prognostic Value of Serum Apolipoprotein A-I Level and Neutrophil-to-Lymphocyte Ratio in Colorectal Cancer Liver Metastasis

Table 2

Univariate and multivariate Cox analysis for OS in patients with CRLM.

Variables	Univariate analysis		Multivariate Analysis
	HR (95%CI)	value	HR (95%CI)	value
Age	1.157 (0.861, 1.555)	0.321
(i) <65 vs. ≥65
Sex	1.305 (0.956, 1.781)	0.076
(i) Male vs. Female
Number of Liver metastases	2.056 (1.538, 2.749)	<0.001	1.760 (1.215, 2.599)	0.004
(i) ≤2 vs. >2
Type of liver metastases	0.539 (0.401, 0.723)	<0.001	0.598 (0.409, 0.862)	0.007
(i) Simultaneous vs. Metachronous
Tumor location	1.482 (1.047, 2.098)	0.012	1.530 (1.086, 2.128)	0.013
(i) LCRC vs. RCC
Pathological type	0.816 (0.456, 1.460)	0.529
(i) Adenocarcinoma vs. nonadenocarcinoma
Degree of tumor differentiation	0.768 (0.506, 1.166)	0.092
(i) Poorly vs. moderately vs. well
cT classification	1.429 (1.077, 1.898)	0.012	1.277 (0.949, 1.720)	0.106
(i) 1-3 vs. 4
cN classification	1.601 (1.189, 2.157)	<0.001	1.422 (1.047, 1.927)	0.024
(i) 0-1 vs. 2-3
KPS scores	1.592 (1.092, 2.322)	0.005	1.396 (0.970, 1.977)	0.066
(i) ≥80 vs. <80
Primary surgery	0.439 (0.316, 0.611)	<0.001	0.659 (0.466, 0.935)	0.019
(i) No vs. Yes
Chemotherapy	0.543 (0.385, 0.767)	<0.001	0.628 (0.452, 0.880)	0.006
(i) No vs. Yes
Targeted therapy	0.794 (0.584, 1.080)	0.161
(i) No vs. Yes
Topical treatment	0.684 (0.505, 0.926)	0.023	0.933 (0.648, 1.321)	0.700
(i) No vs. Yes
Metastasis surgery	0.531 (0.378, 0.747)	0.002	0.978 (0.594, 1.560)	0.928
(i) No vs. Yes
ApoA-I	0.655 (0.493, 0.872)	0.003	0.717 (0.527, 0.976)	0.034
(i) ≤1.03 vs. >1.03
NLR	1.583 (1.191, 2.105)	0.001	1.159 (0.852, 1.578)	0.348
(i) ≤3.24 vs. >3.24

considered as statistically significant.