A Pan-Cancer Analysis on the Systematic Correlation of MutS Homolog 2 (MSH2) to a Malignant Tumor

Figure 9

Enrichment analysis of MSH2-binding proteins and MSH2 expression-related genes. (a) We obtained the result of the experimentally available determination to the MSH2-binding proteins with the STRING tool. (b) We obtain 100 of the genes with the closest association with MSH2 expression. MSH2 expression levels were most positively correlated with MSH6, WDHD1, CDC25A, ERCC6L, and RCC2. (c) The intersection of the above two datasets showed three common genes, MSH6, FANCD2, and EXO1. (d) Information of the corresponding heat map also presented us a positive relationship amid MSH2 and the five genes above in most cancer types.

(a)

(b)

(c)

(d)