Unveiling the Noncanonical Autophagy-Independent Role of ATG7 and ATG9B in Head and Neck Squamous Cell Carcinoma (HNSCC)

Figure 4

ATG7 was involved in the tumor immune microenvironment (TIME) in HNSCC, but did not function in cancer cells. (a) GO analysis of different expression genes with a fold change >1.5 or <0.667 and an based on the mRNA expression of ATG7 in HNSCC in the TCGA database. (b) KEGG analysis of different expression genes with a fold change >1.5 or <0.667 and an based on the mRNA expression of ATG7 in HNSCC in the TCGA database. (c) The correlation between ATG7 expression and tumor purity in HNSCC in the TCGA database. (d–f) ATG7 was positively correlated with PD-L1, PD1, and CTLA4. (g–j) ATG7 was not correlated with PD-L1 in cancer cells in GSE103322. (k) Knockdown of ATG7 did not affect the expression of PD-L1 in the Cal27 HNSCC cell line.

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