Assessing the Variations in Breast/Ovarian Cancer Risk for Chinese BRCA1/2 Carriers

Figure 1

Penetrance estimations of six known Chinese founder mutations. The estimated population lifetime risk of breast cancer for Chinese women (derived from the Gail model) is 0.053; the estimated breast cancer risk in BRCA1/2 carriers is 35–50% (lower bound: 0.35). Great variations in penetrance are observed among the six founder mutations.