Assessing the Variations in Breast/Ovarian Cancer Risk for Chinese BRCA1/2 Carriers

Table 2

Ovarian cancer cluster regions (OCCR) and breast cancer cluster regions (BCCR) in BRCA1 and BRCA2.

Gene	#Bin	No. of carriers	Putative region	Bin-starting nucleotide	Bin-ending nucleotide	Ratio (OR-breast: OR-ovarian)	value	FDR  value
BRCA1	1	58		34	335	0.81 (0.45–1.47)	0.49	0.63
	2	58		397	1115	0.78 (0.44–1.41)	0.4126	0.6189
	3	63	OCCR1	1154	2111	0.29 (0.15–0.57)	0.0001539	0.0012186
	4	58		2127	3229	1.07 (0.61–1.89)	0.8066	0.8066
	5	62		3257	3771	0.78 (0.44–1.37)	0.3852	0.6189
	6	59		3841	4573	0.88 (0.48–1.60)	0.6704	0.7542
	7	58		4609	5095	1.65 (0.92–2.97)	0.09114	0.27342
	8	59		5096	5468-1	1.46 (0.80–2.66)	0.2158	0.48555
	9	66	BCCR1	5470	5524	3.12 (1.65–5.88)	0.0002708	0.0012186
BRCA2	1	41	BCCR2	10	2176	3.47 (1.51–7.96)	0.002485	0.012425
	2	41		2244	4038	1.00 (0.47–2.14)	0.9981	0.9981
	3	48		4151	5723	0.49 (0.23–1.04)	0.0603	0.1005
	4	41	OCCR2	5745	7805 + 1	0.38 (0.16–0.86)	0.01789	0.044725
	5	40		7835	10150	1.63 (0.73–3.62)	0.2281	0.285125

OR: odds ratio; FDR: false discovery rate.