Combining Organoid Models with Next-Generation Sequencing to Reveal Tumor Heterogeneity and Predict Therapeutic Response in Breast Cancer

Table 3

HRD score of the tumor genome.

HRD score: 56
Loss of genome heterozygosity (LOH) score: 25	Telomeric allele imbalance (TAI) score: 20	Transfer of large segments (LST) score: 11

HRD, homologous recombination deficiency. HRD score is the arithmetic sum of LOH, TAI, and LST scores. The threshold of HRD score was 42, and it was positive when HRD score >42, suggesting possible sensitivity to PARP inhibitors, and details should refer to corresponding cancer.