Study on Mechanism of Yiqi Yangyin Jiedu Recipe Inhibiting Triple Negative Breast Cancer Growth: A Network Pharmacology and In Vitro Verification

Figure 5

The mRNA expression of apoptosis-related genes after the treatment of YQYYJDR. The mRNA expressions of CASP8, BAX, CDKN1A, PTEN, BAD, CASP3, MAPK8, GSK3B, and NKX3-1 were upregulated in cancer cells, and the mRNA expressions of AR, FASLG, HIF1A, MMP9, PPARD, RELA, BCL2L1, TGFB1, PTGS2, RAF1, RB1, CASP9, AKT1, PRKCA, BCL2, CTNNB1, E2F1, E2F2, JUN, MDM2, and TP53 were downregulated in cancer cells after the treatment with YQYYJDR.