NF-κB-Activated lncRNACASC9 Promotes Bladder Cancer Progression by Regulating the TK1 Expression

Figure 2

NF-κB activates CASC9 transcription in BC. (a) The CASC9 expression was detected in 5637 and T24 cells transfected with NF-κB siRNAs by qRT-PCR. (b) The CASC9 expression was detected in 5637 and T24 cells transfected with the NF-κB overexpression vector by qRT-PCR. (c) CHIP assays were employed to identify NF-κB occupancy in the CASC9 promoter region. (d) Luciferase reporter assays were conducted to determine the NF-κB binding sites on the CASC9 promoter region. (e) The correlation analysis between NF-κB and CASC9 expression in 30 paired BC samples (, , ). , , and .

(a)

(b)

(c)

(d)

(e)