The Dual Role of USP11 in Cancer

Figure 2

USP11 regulates signaling pathways through deubiquitinating interacting proteins. HPV-16E7: human papillomavirus-16E7 protein; pRb: retinoblastoma protein; Cdc-2: cell division cycle-2 protein; E2F1: E2F transcription factor 1; Bcl-2: B-cell lymphoma-2 protein; BH3: BH3-like motif-containing cell death inducer; FASN: fatty acid synthase; PI3K-S6: phosphoinositide 3-kinase regulatory subunit 6; eIF4B: eukaryotic initiation factor 4B; TNFα: tumor necrosis factor-α; TAK1: transforming growth factor kinase 1; IKKβ: IκB kinase β; NF-κB: nuclear factor-kappa B; IκBα: IkappaB α; ALK5: type I TGFb receptor; TGFβ: transforming growth factor β; TβRII: TGFβ-1 receptor II.