The Dual Role of USP11 in Cancer

Table 3

The proteins are deubiquitinated and stabilized by USP11 and its downstream effects.

Proteins	Effect
RanBPM [12]	Microtubule formation
BRCA2 [13]	DNA repair
cIAP2 [18]	Promoting apoptosis
H2AX [19]	DNA repair
eIF4B [19]	Promoting oncogenic translation
RAE1 [21]	Bipolar spindle formation
E2F1 [48]	Driving Peg10 gene expression
ARID1A [23]	Tumor suppressor function
MLFs [23]	Hematopoiesis and cancer
p53 [24]	Tumor suppressor function
Mgl-1 [31]	Inhibiting cancer
XIAP [29]	Promoting cancer
VGLL4 [39]	Tumor suppressor function
PPP1CA [33]	Activating ERK/MAPK signal
PML [38]	Tumor suppressor function
Snail [38]	Promoting EMT

Abbreviation: RanBPM: RanGTP-binding protein; BRCA2: breast cancer type 2 susceptibility protein; cIAP2: cellular inhibitor of apoptosis proteins; H2AX: histone H2AX; eIF4B: eukaryotic initiation factor 4B; RAE1: ribonucleic acid export protein 1; E2F1: E2F transcription factor 1; ARID1A: AT-rich interactive domain-containing protein 1A; MLFs: myeloid leukemia factors; p53: p53 protein; Mgl-1: Mgl-1 protein; XIAP: x-linked inhibitor of apoptosis protein; VGLL4: vestigial-like4; PPP1CA: serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PML: promyelocytic leukemia; Snail: Zinc finger protein SNAI1; EMT: epithelial-mesenchymal transition.